Month: August 2026

Membranolytic peptide programs immunogenic cell death for cancer therapy

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10899-5The synthetic-acid-responsive membranolytic peptide aMPC16-CA50 induces immunogenic membranolytic cell death in tumour cells, robustly potentiating immune checkpoi…

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10899-5

The synthetic-acid-responsive membranolytic peptide aMPC16-CA50 induces immunogenic membranolytic cell death in tumour cells, robustly potentiating immune checkpoint blockade therapy.

Uncovering the mechanism of female restitution in sugarcane hybrids

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10863-3Female restitution in interspecific sugarcane hybrids between Saccharum officinarum and Saccharum spontaneum arises from second division restitution, as haplotype-…

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10863-3

Female restitution in interspecific sugarcane hybrids between Saccharum officinarum and Saccharum spontaneum arises from second division restitution, as haplotype-resolved F1 genomes reveal duplicated, partially recombined maternal chromatids and distinctive recombination signatures, resolving its meiotic mechanism and enabling breeding strategies to accelerate crop improvement.

Vacuum birefringence and the polarized X-ray emission from a radio magnetar

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10859-zPolarization measurements of the magnetar 1E 1547.0−5408 provide strong evidence that vacuum birefringence shapes X-ray propagation, offering an important observat…

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10859-z

Polarization measurements of the magnetar 1E 1547.0−5408 provide strong evidence that vacuum birefringence shapes X-ray propagation, offering an important observational test of quantum electrodynamics in extreme magnetic fields.

DCAF11-dependent molecular glue degrader activated by glutathionylation

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10873-1M12 is a metabolically activated molecular glue that recruits diverse proteins to DCAF11 for ubiquitin-mediated degradation, revealing a glutathione-dependent mech…

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10873-1

M12 is a metabolically activated molecular glue that recruits diverse proteins to DCAF11 for ubiquitin-mediated degradation, revealing a glutathione-dependent mechanism that broadens targeted protein degradation across multiple substrates.

A compendium of next-generation patient-derived models for diverse cancers

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10806-yThe international collaboration of the Human Cancer Models Initiative presents a comprehensive resource of next-generation cancer models from 2,780 donors with 25 …

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10806-y

The international collaboration of the Human Cancer Models Initiative presents a comprehensive resource of next-generation cancer models from 2,780 donors with 25 cancer types and integrated tumour–model genomic, transcriptomic and epigenomic analyses.

Stimulation modulates gene-linked cell assemblies in the human brain

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10879-9Stimulation of human cortex reorganizes neural assemblies and induces cell-type-specific gene regulatory programs, establishing an ex vivo framework that links sti…

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10879-9

Stimulation of human cortex reorganizes neural assemblies and induces cell-type-specific gene regulatory programs, establishing an ex vivo framework that links stimulation parameters to circuit and transcriptional responses for designing targeted neuromodulatory therapies.

Antigen presentation by CD40<sup>+</sup>MHC-II<sup>+</sup> astrocytes promotes CNS autoimmunity

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10860-6Astrocytes promote central nervous system (CNS) immunity through antigen presentation and activation of CD40 in astrocytes by CD40L expressed by CD4+ T cells in a …

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10860-6

Astrocytes promote central nervous system (CNS) immunity through antigen presentation and activation of CD40 in astrocytes by CD40L expressed by CD4+ T cells in a model of experimental autoimmune encephalomyelitis.