This cholesterol drug promised to be a game-changer. Why did it flop in the clinic — and is there still hope?

Nature, Published online: 03 November 2026; doi:10.1038/d41586-026-03504-2Physicians were excited about several therapies that slash levels of lipoprotein(a) — an important cardiovascular risk factor. One major trial failed to show a b…

Nature, Published online: 03 November 2026; doi:10.1038/d41586-026-03504-2

Physicians were excited about several therapies that slash levels of lipoprotein(a) — an important cardiovascular risk factor. One major trial failed to show a benefit, and now scientists are scrambling to work out what that means.

Will AI grant reviews make science more conservative?

Nature, Published online: 03 November 2026; doi:10.1038/d41586-026-03340-4Researchers are questioning whether outsourcing decisions about research funding to artificial intelligence will reduce scientific novelty.

Nature, Published online: 03 November 2026; doi:10.1038/d41586-026-03340-4

Researchers are questioning whether outsourcing decisions about research funding to artificial intelligence will reduce scientific novelty.

Cities are changing — and architects must adapt

Nature, Published online: 03 November 2026; doi:10.1038/d41586-026-03508-yClimate change is reshaping urban environments. Architect Carlo Ratti tells Nature that technology offers solutions, but citizens must get the final say.

Nature, Published online: 03 November 2026; doi:10.1038/d41586-026-03508-y

Climate change is reshaping urban environments. Architect Carlo Ratti tells Nature that technology offers solutions, but citizens must get the final say.

How democracy depends on science — and must protect it

Nature, Published online: 03 November 2026; doi:10.1038/d41586-026-03510-4Verified information from trusted experts is crucial to help the public and governments navigate rapid changes and increasing complexity.

Nature, Published online: 03 November 2026; doi:10.1038/d41586-026-03510-4

Verified information from trusted experts is crucial to help the public and governments navigate rapid changes and increasing complexity.

Why we’re setting up an institute for radically broad thinking

Nature, Published online: 03 November 2026; doi:10.1038/d41586-026-03397-1The scale of today’s challenges demands a fresh approach — across all disciplines. Here’s how we’re making space for researchers to generate new ideas.

Nature, Published online: 03 November 2026; doi:10.1038/d41586-026-03397-1

The scale of today’s challenges demands a fresh approach — across all disciplines. Here’s how we’re making space for researchers to generate new ideas.

Chinese doctoral students in clinical medicine can graduate without a thesis — more degrees to follow

Nature, Published online: 03 November 2026; doi:10.1038/d41586-026-03480-7Postgraduate students studying professional medicine degrees can qualify with a ‘practical achievement’.

Nature, Published online: 03 November 2026; doi:10.1038/d41586-026-03480-7

Postgraduate students studying professional medicine degrees can qualify with a ‘practical achievement’.