Eukaryotes’ closest relatives are internally simple syntrophic peptidotrophic archaea

Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11170-7Cultures reveal conservation of cell structure, physical symbioses and anaerobiosis across Heimdallarchaeia (the archaeal lineage that branches closest to eukaryo…

Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11170-7

Cultures reveal conservation of cell structure, physical symbioses and anaerobiosis across Heimdallarchaeia (the archaeal lineage that branches closest to eukaryotes) and other Promethearchaeota.

Pharmacological inhibition of METTL1 as a therapy against solid and blood cancers

Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11178-zPharmacological inhibition of the m7G methyltransferase METTL1 in vivo impairs tumour growth and substantially prolongs survival in multiple mouse cancer models o…

Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11178-z

Pharmacological inhibition of the m7G methyltransferase METTL1 in vivo impairs tumour growth and substantially prolongs survival in multiple mouse cancer models of different tissue origin.

Stone and water governed early human settlement of the desert

Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11180-5A geoarchaeological survey of the Rub’ al Khali (the Empty Quarter of Arabia) and spatial modelling of the Arabian Peninsula suggest that human settlement tracked…

Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11180-5

A geoarchaeological survey of the Rub’ al Khali (the Empty Quarter of Arabia) and spatial modelling of the Arabian Peninsula suggest that human settlement tracked the co-occurrence of water and stone suitable for making tools, rather than water alone.

Alzheimer’s disease genetics converges on microglial and neuronal dysregulation

Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11206-yA multi-ancestry study of Alzheimer’s disease identifies new risk loci and potential drug targets, implicates microglia and neurons, and reveals a larger common-v…

Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11206-y

A multi-ancestry study of Alzheimer’s disease identifies new risk loci and potential drug targets, implicates microglia and neurons, and reveals a larger common-variant contribution than previously estimated.

Presynaptic homeostasis mediated by exocytosis of a SNARE protein

Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11201-3Experiments show that when subjected to high-frequency stimulation, excitatory neurons exhibit a presynaptic form of homeostatic plasticity mediated by the exocyt…

Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11201-3

Experiments show that when subjected to high-frequency stimulation, excitatory neurons exhibit a presynaptic form of homeostatic plasticity mediated by the exocytosis of v-SNARE protein VAMP7 and the resulting inhibition of P/Q-type calcium channels.

Time-reversal-symmetry-breaking spin injection from a compensated magnet

Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11227-7Experiments show that altermagnetic Mn5Si3 generates spin currents despite zero net magnetization, demonstrating a central prediction of altermagnetic spintronics.

Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11227-7

Experiments show that altermagnetic Mn5Si3 generates spin currents despite zero net magnetization, demonstrating a central prediction of altermagnetic spintronics.

Ribbon made of carbon pentagons and heptagons has metallic properties

Nature, Published online: 28 October 2026; doi:10.1038/d41586-026-03298-3Ribbons that are composed exclusively of five- and seven-carbon rings have metal-like electron transport and conductance. The ribbons can be synthesized by linkin…

Nature, Published online: 28 October 2026; doi:10.1038/d41586-026-03298-3

Ribbons that are composed exclusively of five- and seven-carbon rings have metal-like electron transport and conductance. The ribbons can be synthesized by linking previously inaccessible chains of paired five-membered rings, providing a route to making highly conducting carbon nanoribbons.

Genetic variants that alter gene regulation in specific cell types are closely tied to disease

Nature, Published online: 28 October 2026; doi:10.1038/d41586-026-03067-2Single-cell profiling of nearly 2,000 people brings scientists closer to understanding the link between genetic variation, gene expression and health.

Nature, Published online: 28 October 2026; doi:10.1038/d41586-026-03067-2

Single-cell profiling of nearly 2,000 people brings scientists closer to understanding the link between genetic variation, gene expression and health.