A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activation

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11093-3Proteomic and phosphoproteomic analyses of lysosomes identify a nutrient-independent regulatory arm of mTORC1 signalling that mediates lysosomal adaptation to s…

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11093-3

Proteomic and phosphoproteomic analyses of lysosomes identify a nutrient-independent regulatory arm of mTORC1 signalling that mediates lysosomal adaptation to stress and whose deregulation underlies tumorigenesis in follicular lymphoma.

Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11087-1By being restricted to target regions by MLLT1–MLLT3 occupancy, activation-induced deaminase activity is able to avoid most off-target mutagenesis during B cell…

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11087-1

By being restricted to target regions by MLLT1–MLLT3 occupancy, activation-induced deaminase activity is able to avoid most off-target mutagenesis during B cell somatic hypermutation.

Self-aligned optical microcomb emerging between octave-separated lasers

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11086-2An architectural inversion shifts integrated optical frequency comb generation from outward broadening around a central pump to filling the spectrum between two…

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11086-2

An architectural inversion shifts integrated optical frequency comb generation from outward broadening around a central pump to filling the spectrum between two octave-separated pumps through a self-aligned parametrically driven cavity soliton, enabling robust self-referencing for future deployable on-chip frequency and time metrology.

X-ray liquidography decodes complex motions in azobenzene isomerization

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11068-4Time-resolved X-ray liquidography films the structural changes of azobenzene during trans-to-cis isomerization in solution with atomic-level precision.

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11068-4

Time-resolved X-ray liquidography films the structural changes of azobenzene during trans-to-cis isomerization in solution with atomic-level precision.

Evolution of terrestrial anatomy revealed by a derived stem tetrapod

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11090-6New anatomical evidence reclassifies Westlothiana as an aquatic stem tetrapod, showing that terrestrial limb adaptations evolved mosaically in transitional amph…

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11090-6

New anatomical evidence reclassifies Westlothiana as an aquatic stem tetrapod, showing that terrestrial limb adaptations evolved mosaically in transitional amphibious environments before crown tetrapods emerged.

Global mangrove distribution on the open coast is controlled by waves

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11089-zA process-driven mangrove presence or absence model using 20 years of open-source wave data shows that wave conditions are critical in determining where mangrov…

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11089-z

A process-driven mangrove presence or absence model using 20 years of open-source wave data shows that wave conditions are critical in determining where mangroves grow worldwide.

Spatiotemporal clonal architecture of the newborn mouse forebrain

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11064-8Clonal barcoding across the newborn mouse forebrain reveals developmental principles whereby glutamatergic neurons and astrocytes remain locally derived, wherea…

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11064-8

Clonal barcoding across the newborn mouse forebrain reveals developmental principles whereby glutamatergic neurons and astrocytes remain locally derived, whereas widely dispersed GABAergic (γ-aminobutyric acid-producing) lineages link neurons with oligodendrocyte precursor cells.

Type 2 immune history trains lung macrophages for viral disease tolerance

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11060-yType 2 inflammation trains nerve- and airway-associated macrophages to confer disease tolerance against lethal influenza by limiting immunopathology and promoti…

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11060-y

Type 2 inflammation trains nerve- and airway-associated macrophages to confer disease tolerance against lethal influenza by limiting immunopathology and promoting tissue repair without enhancing viral clearance.