‘Historic change’: what the 2026 US mid-term election results mean for science

Nature, Published online: 04 November 2026; doi:10.1038/d41586-026-03579-xResearchers hope that US lawmakers will push back against the Trump administration’s science policies — but there are limits to what Congress can do.

Nature, Published online: 04 November 2026; doi:10.1038/d41586-026-03579-x

Researchers hope that US lawmakers will push back against the Trump administration’s science policies — but there are limits to what Congress can do.

Rise of Germanic and Celtic languages is written in ancient DNA

Nature, Published online: 04 November 2026; doi:10.1038/d41586-026-03581-3Thousands of genome sequences identify human migrations that might have spread early forms of these tongues around Europe.

Nature, Published online: 04 November 2026; doi:10.1038/d41586-026-03581-3

Thousands of genome sequences identify human migrations that might have spread early forms of these tongues around Europe.

Decoding the regulatory programs governing glioblastoma plasticity

Nature, Published online: 04 November 2026; doi:10.1038/s41586-026-11177-0Multi-omic analyses of cells from patients with glioblastoma (GB) provide insight into the role of non-genetic cellular plasticity in disease progression, showin…

Nature, Published online: 04 November 2026; doi:10.1038/s41586-026-11177-0

Multi-omic analyses of cells from patients with glioblastoma (GB) provide insight into the role of non-genetic cellular plasticity in disease progression, showing that state stability in GB cells is controlled by a network of interacting activators and repressors.

Spider snooze stages

Nature, Published online: 04 November 2026; doi:10.1038/d41586-026-03487-0How similar are vertebrate and invertebrate sleeping behaviours? An analysis of spiders offers insights about how sleep evolved.

Nature, Published online: 04 November 2026; doi:10.1038/d41586-026-03487-0

How similar are vertebrate and invertebrate sleeping behaviours? An analysis of spiders offers insights about how sleep evolved.

Comprehensive mapping of essential-gene interactions in <i>M. tuberculosis</i>

Nature, Published online: 04 November 2026; doi:10.1038/s41586-026-11212-0A high-throughput CRISPR-interference platform allows the mapping of interactions between essential genes in Mycobacterium tuberculosis, revealing many previousl…

Nature, Published online: 04 November 2026; doi:10.1038/s41586-026-11212-0

A high-throughput CRISPR-interference platform allows the mapping of interactions between essential genes in Mycobacterium tuberculosis, revealing many previously unknown genetic interactions and providing insight into gene function and drug–target relationships that could enable the development of new therapies for tuberculosis.

A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity

Nature, Published online: 04 November 2026; doi:10.1038/s41586-026-11234-8A deep single-cell and spatial multi-omic atlas of human glioblastoma is generated, pairing transcriptomic, epigenomic and genomic profiling, and tracing gliobla…

Nature, Published online: 04 November 2026; doi:10.1038/s41586-026-11234-8

A deep single-cell and spatial multi-omic atlas of human glioblastoma is generated, pairing transcriptomic, epigenomic and genomic profiling, and tracing glioblastoma tumour heterogeneity to a stereotyped and spatially patterned trajectory of cancer cells.

A conserved flowering-time module underlies double-season cropping

Nature, Published online: 04 November 2026; doi:10.1038/s41586-026-11187-yThe genomic footprints of 80 years of modern breeding in China are traced using representative cultivars, demonstrating how precision genome editing can be used …

Nature, Published online: 04 November 2026; doi:10.1038/s41586-026-11187-y

The genomic footprints of 80 years of modern breeding in China are traced using representative cultivars, demonstrating how precision genome editing can be used to reconstruct adaptive modules for climate-resilient crop design.