Population-scale immune multiome atlas reveals regulatory disease mechanisms

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11078-2Population-scale simultaneous profiling of chromatin accessibility and gene expression across immune cells reveals regulatory architectures that connect genetic…

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11078-2

Population-scale simultaneous profiling of chromatin accessibility and gene expression across immune cells reveals regulatory architectures that connect genetic variants to disease.

Secret watermark labels proteins as ‘made by AI’

Nature, Published online: 30 September 2026; doi:10.1038/d41586-026-03033-yAn innovative safeguard could help to flag proteins devised by artificial-intelligence tools such as AlphaFold, but the digital marker can be erased.

Nature, Published online: 30 September 2026; doi:10.1038/d41586-026-03033-y

An innovative safeguard could help to flag proteins devised by artificial-intelligence tools such as AlphaFold, but the digital marker can be erased.

These optical illusions are why butterflies are so hard to catch

Nature, Published online: 30 September 2026; doi:10.1038/d41586-026-03124-wHigh-speed footage of takeoffs reveal that the butterfly markings mislead the eye, making them harder to catch.

Nature, Published online: 30 September 2026; doi:10.1038/d41586-026-03124-w

High-speed footage of takeoffs reveal that the butterfly markings mislead the eye, making them harder to catch.

A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activation

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11093-3Proteomic and phosphoproteomic analyses of lysosomes identify a nutrient-independent regulatory arm of mTORC1 signalling that mediates lysosomal adaptation to s…

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11093-3

Proteomic and phosphoproteomic analyses of lysosomes identify a nutrient-independent regulatory arm of mTORC1 signalling that mediates lysosomal adaptation to stress and whose deregulation underlies tumorigenesis in follicular lymphoma.

Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11087-1By being restricted to target regions by MLLT1–MLLT3 occupancy, activation-induced deaminase activity is able to avoid most off-target mutagenesis during B cell…

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11087-1

By being restricted to target regions by MLLT1–MLLT3 occupancy, activation-induced deaminase activity is able to avoid most off-target mutagenesis during B cell somatic hypermutation.

Self-aligned optical microcomb emerging between octave-separated lasers

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11086-2An architectural inversion shifts integrated optical frequency comb generation from outward broadening around a central pump to filling the spectrum between two…

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11086-2

An architectural inversion shifts integrated optical frequency comb generation from outward broadening around a central pump to filling the spectrum between two octave-separated pumps through a self-aligned parametrically driven cavity soliton, enabling robust self-referencing for future deployable on-chip frequency and time metrology.

X-ray liquidography decodes complex motions in azobenzene isomerization

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11068-4Time-resolved X-ray liquidography films the structural changes of azobenzene during trans-to-cis isomerization in solution with atomic-level precision.

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11068-4

Time-resolved X-ray liquidography films the structural changes of azobenzene during trans-to-cis isomerization in solution with atomic-level precision.