Iconic first image of black hole holds up to scrutiny

Nature, Published online: 11 November 2026; doi:10.1038/d41586-026-03642-7Picture produced by fresh analysis of the data that yielded the first-ever image of a black hole outputs the same, ring-like shape.

Nature, Published online: 11 November 2026; doi:10.1038/d41586-026-03642-7

Picture produced by fresh analysis of the data that yielded the first-ever image of a black hole outputs the same, ring-like shape.

Evolutionary dynamics in the years preceding acute myeloid leukaemia

Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11269-xThe somatic evolutionary histories of haematopoietic cells in the years preceding acute myeloid leukaemia diagnosis show that the clonal dynamics of blood comply…

Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11269-x

The somatic evolutionary histories of haematopoietic cells in the years preceding acute myeloid leukaemia diagnosis show that the clonal dynamics of blood comply with a set of simple evolutionary rules.

Mitochondrial protein import defects enhance tumour immunogenicity

Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11249-1Inhibition of mitochondrial protein import can enhance tumour immunogenicity by promoting mitochondrial DNA release.

Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11249-1

Inhibition of mitochondrial protein import can enhance tumour immunogenicity by promoting mitochondrial DNA release.

Human replisomes direct a dedicated leading-strand primase for fork restart

Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11204-0Structural and biochemical studies show that the CMG helicase directly recruits PRIMPOL for leading-strand repriming, enabling replication fork restart and limit…

Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11204-0

Structural and biochemical studies show that the CMG helicase directly recruits PRIMPOL for leading-strand repriming, enabling replication fork restart and limiting post-replicative DNA gaps.

Low-power 2D CFETs using single-crystal high-<i>κ</i> dielectrics

Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11272-2A transferable single-crystal anatase titanium dioxide dielectric enables high-quality interfaces with two-dimensional semiconductors, yielding near-ideal switch…

Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11272-2

A transferable single-crystal anatase titanium dioxide dielectric enables high-quality interfaces with two-dimensional semiconductors, yielding near-ideal switching, low hysteresis and ultra-low-power complementary transistors and inverters.

Glycosylation and importins liquefy the FG barrier in live nuclear pores

Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11258-0Nuclear pore proteins maintain a fluid, spatially organized barrier through coordinated molecular interactions, explaining how cells achieve selective transport …

Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11258-0

Nuclear pore proteins maintain a fluid, spatially organized barrier through coordinated molecular interactions, explaining how cells achieve selective transport and reconciling competing models of pore structure.

Personal incentives for public officials drove a drop in China’s fertility

Nature, Published online: 11 November 2026; doi:10.1038/d41586-026-03274-xOnce the promotion prospects of bureaucrats became tied to birth targets, the country’s one-child policy became more effective. Can the state now reverse this ef…

Nature, Published online: 11 November 2026; doi:10.1038/d41586-026-03274-x

Once the promotion prospects of bureaucrats became tied to birth targets, the country’s one-child policy became more effective. Can the state now reverse this effect?

The molecular basis of replication fork restart via repriming by PRIMPOL

Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11276-yPRIMPOL is recruited to stalled forks through an interaction with the replicative helicase CDC45–MCM2–7–GINS, facilitating primer handover from PRIMPOL to the hi…

Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11276-y

PRIMPOL is recruited to stalled forks through an interaction with the replicative helicase CDC45–MCM2–7–GINS, facilitating primer handover from PRIMPOL to the high-fidelity polymerase ε, minimizing mutagenic DNA synthesis.

Proposed approach for diagnosing obesity outperforms old method

Nature, Published online: 11 November 2026; doi:10.1038/d41586-026-03425-0A framework for diagnosing obesity that was proposed in 2025 incorporates waist circumference and related measures and distinguishes clinical from preclinical ob…

Nature, Published online: 11 November 2026; doi:10.1038/d41586-026-03425-0

A framework for diagnosing obesity that was proposed in 2025 incorporates waist circumference and related measures and distinguishes clinical from preclinical obesity on the basis of obesity-induced organ dysfunction. In an international multi-cohort study of 844,108 adults, this framework outperformed conventional body-mass-index-based criteria in diagnosing obesity and stratifying mortality risk.