Multimodal precision diagnostics in clinical xenotransplantation

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11096-0Now that hyperacute rejection of pig xenografts can be reliably prevented, subtler immune-mediated graft injuries have emerged that conventional diagnostics often…

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11096-0

Now that hyperacute rejection of pig xenografts can be reliably prevented, subtler immune-mediated graft injuries have emerged that conventional diagnostics often miss; a multimodal precision diagnostic framework is proposed to detect these injuries earlier, guide personalized immunosuppression and inform future gene editing strategies.