How long-term dietary cholesterol can slow down its own clearance by liver cells

Nature, Published online: 25 June 2026; doi:10.1038/d41586-026-01899-6Cholesterol carried by low-density lipoprotein (LDL) drives heart disease and is cleared by liver cells expressing the receptor LDLR. A cell-signalling mechanism has…

Nature, Published online: 25 June 2026; doi:10.1038/d41586-026-01899-6

Cholesterol carried by low-density lipoprotein (LDL) drives heart disease and is cleared by liver cells expressing the receptor LDLR. A cell-signalling mechanism has been discovered through which high cholesterol promotes the enzyme-mediated degradation of LDLR. Blocking this enzyme restores LDLR levels in liver cells, suggesting a new strategy for treating high cholesterol.

Crude oil turns cheap porous membrane into a sieve to refine itself without heat

Nature, Published online: 24 June 2026; doi:10.1038/d41586-026-01896-9An inexpensive, porous polymer membrane helps to separate raw crude oil, without heat or selective coating. Heavy hydrocarbons self-assemble inside the pores to crea…

Nature, Published online: 24 June 2026; doi:10.1038/d41586-026-01896-9

An inexpensive, porous polymer membrane helps to separate raw crude oil, without heat or selective coating. Heavy hydrocarbons self-assemble inside the pores to create channels that are likely to be less than 2 nanometres wide, enriching the resulting permeate mix into light, ‘naphtha range’ hydrocarbons with 30% less energy cost and carbon dioxide emissions than conventional distillation.

AI tool spots antibiotics that fight drug-resistant gonorrhoea

Nature, Published online: 24 June 2026; doi:10.1038/d41586-026-01987-7The bacterium Neisseria gonorrhoeae has evolved resistance to most antibiotics used to treat it, but a machine-learning screen reveals potential therapies.

Nature, Published online: 24 June 2026; doi:10.1038/d41586-026-01987-7

The bacterium Neisseria gonorrhoeae has evolved resistance to most antibiotics used to treat it, but a machine-learning screen reveals potential therapies.

Long-sought chemical inhibitors of β-arrestin proteins

Nature, Published online: 24 June 2026; doi:10.1038/d41586-026-01894-xProteins called β-arrestins regulate signalling through members of the G protein-coupled receptor (GPCR) superfamily. Small molecules that bind directly to the β-arr…

Nature, Published online: 24 June 2026; doi:10.1038/d41586-026-01894-x

Proteins called β-arrestins regulate signalling through members of the G protein-coupled receptor (GPCR) superfamily. Small molecules that bind directly to the β-arrestins and inhibit their activities are the first chemical tools to probe their biology, opening avenues for transducer-targeted, pathway-specific GPCR therapeutics.

A 1970s patent that changed the course of commercial biotechnology

Nature, Published online: 23 June 2026; doi:10.1038/d41586-026-01812-1The scientific community awaits a patent for recombinant DNA technology, and experimentation with an anaesthetic from puffballs, in our weekly dip into Nature’s arch…

Nature, Published online: 23 June 2026; doi:10.1038/d41586-026-01812-1

The scientific community awaits a patent for recombinant DNA technology, and experimentation with an anaesthetic from puffballs, in our weekly dip into Nature’s archive.

Europe must seize the moment to lead on free and open science

Nature, Published online: 23 June 2026; doi:10.1038/d41586-026-01953-3An under-appreciated research powerhouse, Europe has a responsibility to champion democratic science that is accessible to all the world’s research talent.

Nature, Published online: 23 June 2026; doi:10.1038/d41586-026-01953-3

An under-appreciated research powerhouse, Europe has a responsibility to champion democratic science that is accessible to all the world’s research talent.