Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11276-y
PRIMPOL is recruited to stalled forks through an interaction with the replicative helicase CDC45–MCM2–7–GINS, facilitating primer handover from PRIMPOL to the high-fidelity polymerase ε, minimizing mutagenic DNA synthesis.The molecular basis of replication fork restart via repriming by PRIMPOL
Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11276-yPRIMPOL is recruited to stalled forks through an interaction with the replicative helicase CDC45–MCM2–7–GINS, facilitating primer handover from PRIMPOL to the hi…