Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11204-0
Structural and biochemical studies show that the CMG helicase directly recruits PRIMPOL for leading-strand repriming, enabling replication fork restart and limiting post-replicative DNA gaps.Human replisomes direct a dedicated leading-strand primase for fork restart
Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11204-0Structural and biochemical studies show that the CMG helicase directly recruits PRIMPOL for leading-strand repriming, enabling replication fork restart and limit…