Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10697-z
Chronic dietary cholesterol activates Ral GTPases, which promote LDLR internalization and lysosomal degradation through RalBP1–REPS1 and CTSA, thereby reducing cholesterol clearance, whereas CTSA inhibition restores LDLR function and may offer a therapeutic strategy for cardiovascular disease.Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover
Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10697-zChronic dietary cholesterol activates Ral GTPases, which promote LDLR internalization and lysosomal degradation through RalBP1–REPS1 and CTSA, thereby reducing chole…