Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10729-8
Different RNA modifications elicit different translation elongation rates for in vitro transcribed mRNAs that result in disparate translation outputs and fidelity, as shown here for N4-acetylcytidine versus the industry standard for synthetic mRNAs, N1-methylpseudouridine.<i>N</i><sup>4</sup>-Acetylcytidine enhances synthetic mRNA translation yield and fidelity
Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10729-8Different RNA modifications elicit different translation elongation rates for in vitro transcribed mRNAs that result in disparate translation outputs and fidelity, a…