Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10705-2
TROP2 marks poor-prognosis colorectal cancer cells with fetal-like, therapy-resistant states, and therapeutic targeting of TROP2 with antibody–drug conjugates in combination with chemotherapy enhances treatment efficacy by modulating tumour cell plasticity and overcoming resistance.TROP2 targeting reveals therapy-driven cell state dynamics in colorectal cancer
Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10705-2TROP2 marks poor-prognosis colorectal cancer cells with fetal-like, therapy-resistant states, and therapeutic targeting of TROP2 with antibody–drug conjugates in com…