Ketogenic diet mediates intestinal tumorigenesis through lipids not ketones

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10779-yA combination of different manipulations in mouse models of spontaneous intestinal adenoma formation dissects the roles of systemic and epithelial ketogenesis versus…

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10779-y

A combination of different manipulations in mouse models of spontaneous intestinal adenoma formation dissects the roles of systemic and epithelial ketogenesis versus dietary lipids in ketogenic diet-mediated intestinal tumorigenesis, highlighting the need for nuanced consideration of dietary strategies for cancer prevention.