Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10819-7
Kilobase-scale nickase-targeting (KNIT) editing enables single-nick-based DNA insertion across genomic loci and cell types, supporting insertion of DNA fragments exceeding 10 kb, with high efficiency and minimal unwanted off-target effects.Efficient and precise programmable DNA knock-in without double-strand breaks
Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10819-7Kilobase-scale nickase-targeting (KNIT) editing enables single-nick-based DNA insertion across genomic loci and cell types, supporting insertion of DNA fragments exc…