Tertiary lymphoid structures harbour stem-like tumour-specific T cells

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10808-wRenal cell carcinoma tumours containing tertiary lymphoid structures (TLSs) are enriched for exhausted CD8+ T cells, including tumour-specific clonotypes with stem-l…

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10808-w

Renal cell carcinoma tumours containing tertiary lymphoid structures (TLSs) are enriched for exhausted CD8+ T cells, including tumour-specific clonotypes with stem-like progenitor features and reduced terminal exhaustion.