AI identifies interactions in CRISPR complexes to improve specificity of DNA editing

Nature, Published online: 22 July 2026; doi:10.1038/d41586-026-02042-1AlphaFold3 predictions of the molecular contacts made by a genome-editing enzyme have been used to improve the enzyme’s selectivity for target DNA sequences.

Nature, Published online: 22 July 2026; doi:10.1038/d41586-026-02042-1

AlphaFold3 predictions of the molecular contacts made by a genome-editing enzyme have been used to improve the enzyme’s selectivity for target DNA sequences.