Temporal uncoupling of radial glia lineage progression in cortical organoids

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10916-7RGP lineage tracing in stem-cell-derived organoids shows highly plastic proliferation and reduced clonal neuronal diversity, indicating that missing non-cell-auton…

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10916-7

RGP lineage tracing in stem-cell-derived organoids shows highly plastic proliferation and reduced clonal neuronal diversity, indicating that missing non-cell-autonomous niche cues are essential for faithful temporal control of cortical lineage progression.