Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10886-w
CDK4/6 inhibition redirects Rb chromatin occupancy to activate oestrogen-responsive genes, counteracting its own ability to maintain therapeutic cell-cycle arrest.Rb-driven transcription limits its tumour-suppressive effects in breast cancer
Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10886-wCDK4/6 inhibition redirects Rb chromatin occupancy to activate oestrogen-responsive genes, counteracting its own ability to maintain therapeutic cell-cycle arrest.