Nature, Published online: 19 August 2026; doi:10.1038/s41586-026-10933-6
A one-pot skeletal-editing reaction replaces isoxazole oxygen with carbon to form challenging pyrroles, enabled by an N-propargylic enaminone intermediate and a computational model predicting reaction outcomes.Synthesis of pyrroles from isoxazoles by an O-to-C skeletal edit
Nature, Published online: 19 August 2026; doi:10.1038/s41586-026-10933-6A one-pot skeletal-editing reaction replaces isoxazole oxygen with carbon to form challenging pyrroles, enabled by an N-propargylic enaminone intermediate and a co…