Human brain organoids record the passage of time over multiple years

Nature, Published online: 19 August 2026; doi:10.1038/s41586-026-10877-xHuman brain organoids were developed for over five years in culture to demonstrate that brain cells can continue to mature and record the passage of time, followin…

Nature, Published online: 19 August 2026; doi:10.1038/s41586-026-10877-x

Human brain organoids were developed for over five years in culture to demonstrate that brain cells can continue to mature and record the passage of time, following human-specific endogenous programs, even outside the context of the organism.