Cohesin reshapes replication fork contacts to aid fork slowing and reversal

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11034-0Cohesin-mediated loop extrusion limits sister-fork coupling and tethers nearby replication forks under replication stress, promoting fork reversal and slowing f…

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11034-0

Cohesin-mediated loop extrusion limits sister-fork coupling and tethers nearby replication forks under replication stress, promoting fork reversal and slowing fork progression to safeguard genome stability.