Hepatocytes promote liver metastasis of pancreatic cancer by providing serine

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11051-zMetastatic pancreatic ductal adenocarcinoma (PDAC) in the liver that lack the enzyme necessary to synthesize serine can reprogram hepatocytes to produce this am…

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11051-z

Metastatic pancreatic ductal adenocarcinoma (PDAC) in the liver that lack the enzyme necessary to synthesize serine can reprogram hepatocytes to produce this amino acid, thus promoting tumour growth and survival.