Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11054-w
Reactive astrocytes emerge as a primary consequence of TSC2 loss in tuberous sclerosis complex, implicating glial dysfunction as a primary driver of pathogenesis and highlighting the astrocytes as potential therapeutic targets for tuberous sclerosis complex-related neuropathology.mTORC1 drives cell-autonomous astrocyte reactivity in tuberous sclerosis
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11054-wReactive astrocytes emerge as a primary consequence of TSC2 loss in tuberous sclerosis complex, implicating glial dysfunction as a primary driver of pathogenesi…