Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11059-5
ZMYND8 suppresses IL-2R–STAT5 signalling by inhibiting p300-mediated transcriptional activation of Il2ra to enforce CD8+ T cell terminal exhaustion, and its deletion boosts effector-like states and markedly enhances antiviral and antitumour immunity.Targeting ZMYND8 unleashes IL-2 signalling to override T cell exhaustion
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11059-5ZMYND8 suppresses IL-2R–STAT5 signalling by inhibiting p300-mediated transcriptional activation of Il2ra to enforce CD8+ T cell terminal exhaustion, and its del…