Lifespan single-cell transcriptomic atlas of the human prefrontal cortex

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-10271-7The dorsolateral prefrontal cortex exhibits non-linear, cell-type-specific transcriptional trajectories characterized by dynamic remodelling during development,…

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-10271-7

The dorsolateral prefrontal cortex exhibits non-linear, cell-type-specific transcriptional trajectories characterized by dynamic remodelling during development, relative stability in midlife and selective molecular reactivation in late adulthood.