Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11088-0
A strategy for functional G-protein-coupled receptor (GPCR) antagonism through bispecific antibody-mediated endocytosis and lysosomal degradation is reported.GPCR antagonism via rewiring of receptor trafficking and degradation
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11088-0A strategy for functional G-protein-coupled receptor (GPCR) antagonism through bispecific antibody-mediated endocytosis and lysosomal degradation is reported.