Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11087-1
By being restricted to target regions by MLLT1–MLLT3 occupancy, activation-induced deaminase activity is able to avoid most off-target mutagenesis during B cell somatic hypermutation.Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11087-1By being restricted to target regions by MLLT1–MLLT3 occupancy, activation-induced deaminase activity is able to avoid most off-target mutagenesis during B cell…