A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activation

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11093-3Proteomic and phosphoproteomic analyses of lysosomes identify a nutrient-independent regulatory arm of mTORC1 signalling that mediates lysosomal adaptation to s…

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11093-3

Proteomic and phosphoproteomic analyses of lysosomes identify a nutrient-independent regulatory arm of mTORC1 signalling that mediates lysosomal adaptation to stress and whose deregulation underlies tumorigenesis in follicular lymphoma.