RNA catalysis emerges from dynamic structural ensembles

Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11140-zRNase P RNA forms shifting active and inactive conformers whose catalytic activity depends on Mg2+-driven tertiary-interaction dynamics, which are modulated by bi…

Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11140-z

RNase P RNA forms shifting active and inactive conformers whose catalytic activity depends on Mg2+-driven tertiary-interaction dynamics, which are modulated by binding of accessory proteins.