Replication-stress-induced chromatin loops protect fork stability

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10695-1Replication stress induces the formation of transient chromatin loops that enclose de novo heterochromatin-enriched stalled replication forks.

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10695-1

Replication stress induces the formation of transient chromatin loops that enclose de novo heterochromatin-enriched stalled replication forks.

A secreted endosymbiont protein essential for colonizing host cells

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10711-4SyeA was present in the Buchnera ancestor, is secreted into the host cytoplasm, is homologous to secreted effectors of bacterial pathogens and is essential for Buchn…

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10711-4

SyeA was present in the Buchnera ancestor, is secreted into the host cytoplasm, is homologous to secreted effectors of bacterial pathogens and is essential for Buchnera transmission.

Targeted enzyme discovery using metal-coordination mining

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10716-zA methodology for mining protein structure databases on the basis of the distinct intrinsic structures of metal-binding active sites in enzymes enables the discovery…

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10716-z

A methodology for mining protein structure databases on the basis of the distinct intrinsic structures of metal-binding active sites in enzymes enables the discovery of new families of radical halogenases.

Identification of cross-stage, cross-species malaria CD8<sup>+</sup> T cell antigens

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10730-1An immunopeptidomics analysis identifies numerous Plasmodium T cell antigens that are conserved across malaria parasite species and expressed at several phases of th…

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10730-1

An immunopeptidomics analysis identifies numerous Plasmodium T cell antigens that are conserved across malaria parasite species and expressed at several phases of the parasite’s life cycle, with possible applications in the development of a malaria vaccine.

Nanodiamonds made from tiny graphene triangles

Nature, Published online: 01 July 2026; doi:10.1038/d41586-026-02001-wNanodiamonds can host atom-sized light emitters for quantum sensing and imaging, but making nanodiamonds that are small, crystalline and uniform has been difficult. …

Nature, Published online: 01 July 2026; doi:10.1038/d41586-026-02001-w

Nanodiamonds can host atom-sized light emitters for quantum sensing and imaging, but making nanodiamonds that are small, crystalline and uniform has been difficult. A single-step process for making nanodiamonds only 3–4 nanometres in size uses planar carbon ‘nanographene’ molecules with hydrogen atoms on the edges, and can be adapted to generate fluorescent nanodiamonds.

<i>Urokodia</i> sheds light on the origin of chelicerae and book gills of Chelicerata

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10713-2Microtomography reconstructions and phylogenetic analyses of Urokodia aequalis from the Chengjiang biota of China provide an updated interpretation of the evolution …

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10713-2

Microtomography reconstructions and phylogenetic analyses of Urokodia aequalis from the Chengjiang biota of China provide an updated interpretation of the evolution of anatomical structures in chelicerates.

Correcting congenital myasthenia-associated acetylcholine receptor defects

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10706-1Cryogenic electron microscopy, chemical biology and electrophysiology are used to determine the structures and functional consequences of representative congenital m…

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10706-1

Cryogenic electron microscopy, chemical biology and electrophysiology are used to determine the structures and functional consequences of representative congenital myasthenic syndrome-associated mutant receptors with and without drugs, uncovering principles of pathogenesis and providing a framework for precision therapies.

Seeking universal malaria-vaccine targets

Nature, Published online: 01 July 2026; doi:10.1038/d41586-026-01808-xEvolutionarily conserved targets have been identified that are shared across malaria-parasite species and their life stages and are recognized by the human immune sy…

Nature, Published online: 01 July 2026; doi:10.1038/d41586-026-01808-x

Evolutionarily conserved targets have been identified that are shared across malaria-parasite species and their life stages and are recognized by the human immune system.

Paper mill cancer studies get double the number of citations as genuine papers

Nature, Published online: 01 July 2026; doi:10.1038/d41586-026-01908-8Potentially fraudulent papers often cite each other and could be inflating the impact factor of journals in which they are published.

Nature, Published online: 01 July 2026; doi:10.1038/d41586-026-01908-8

Potentially fraudulent papers often cite each other and could be inflating the impact factor of journals in which they are published.