Dose once, treat forever: drugs are being engineered to last much longer

Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02660-9Medication that persists inside the body for months or years could transform the treatment and prevention of many conditions — especially in low- and middle-inc…

Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02660-9

Medication that persists inside the body for months or years could transform the treatment and prevention of many conditions — especially in low- and middle-income countries.

TM184C is a GPCR-like regulator of intercellular exchange and autophagy

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10993-8TM184C—an ancient G-protein-coupled receptor-like superdark protein involved in regulation of autophagy, intercellular connectivity and material exchange—unders…

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10993-8

TM184C—an ancient G-protein-coupled receptor-like superdark protein involved in regulation of autophagy, intercellular connectivity and material exchange—underscores the promise of exploring the understudied human proteome and beyond.

Family-based analyses show how children’s genetics shape key traits

Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02689-wThe Norwegian Mother, Father and Child Cohort Study, called MoBa, includes genetic data from around 230,000 parents and children. Using about 44,000 father–moth…

Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02689-w

The Norwegian Mother, Father and Child Cohort Study, called MoBa, includes genetic data from around 230,000 parents and children. Using about 44,000 father–mother–child trios, child and parental genetics were modelled together to estimate the effects of the children’s own genetic differences on their height, educational achievement, sleep duration and depressive symptoms.

Integrated signatures define mutational processes in prostate cancer

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10468-wEight integrated mutational footprints collectively explain the mutational processes in 85% of primary prostate cancer genomes.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10468-w

Eight integrated mutational footprints collectively explain the mutational processes in 85% of primary prostate cancer genomes.

The Einstein test: what happens when AI tries to rediscover relativity?

Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02804-xScientists are probing whether language models trained on historical data can reproduce creative breakthroughs.

Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02804-x

Scientists are probing whether language models trained on historical data can reproduce creative breakthroughs.

Anodic Pd membrane H<sub>2</sub> extraction enhances thermochemical dehydrogenation

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11008-2An electrochemical cell with molten hydroxide and a Pd membrane actively extracts H2 and thereby boosts ammonia and methylcyclohexane conversion, while also del…

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11008-2

An electrochemical cell with molten hydroxide and a Pd membrane actively extracts H2 and thereby boosts ammonia and methylcyclohexane conversion, while also delivering purified H2 ready for use.

Phone-call tutorials improve learning cost-effectively during education emergencies

Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02700-4Across five randomized trials in India, Kenya, Nepal, the Philippines and Uganda, weekly 20-minute mobile-phone-call tutorials produced large learning gains for…

Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02700-4

Across five randomized trials in India, Kenya, Nepal, the Philippines and Uganda, weekly 20-minute mobile-phone-call tutorials produced large learning gains for primary-school children during school closures caused by the COVID-19 pandemic. Governments can keep children learning through societal shocks using this approach, which combines low-cost, high-access mobile-phone technology with high-quality tutoring targeted to each child’s learning level.

TRI-611, a selective, brain-penetrant molecular glue degrader of ALK

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10998-3TRI-611 induces the degradation of ALK fusion proteins via a previously undescribed CRBN recruitment motif, and its preclinical anti-tumour activity highlights …

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10998-3

TRI-611 induces the degradation of ALK fusion proteins via a previously undescribed CRBN recruitment motif, and its preclinical anti-tumour activity highlights TRI-611 as a potential new way of treating ALK-positive non-small-cell lung cancer.

Why we need an International Panel on Inequality

Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02806-9Disparities in income and wealth are growing. A scientific assessment process can give governments the information they need to tackle them.

Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02806-9

Disparities in income and wealth are growing. A scientific assessment process can give governments the information they need to tackle them.

Imaging cellular activity across all organs reveals body-wide circuits

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10979-6An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distribu…

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10979-6

An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.