Genetic background sets the trajectory of experimental cancer evolution

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10821-zExperimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving muta…

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10821-z

Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stages of cancer development.

Efficient and precise programmable DNA knock-in without double-strand breaks

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10819-7Kilobase-scale nickase-targeting (KNIT) editing enables single-nick-based DNA insertion across genomic loci and cell types, supporting insertion of DNA fragments exc…

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10819-7

Kilobase-scale nickase-targeting (KNIT) editing enables single-nick-based DNA insertion across genomic loci and cell types, supporting insertion of DNA fragments exceeding 10 kb, with high efficiency and minimal unwanted off-target effects.

Daily briefing: Can the world finally eradicate polio?

Nature, Published online: 22 July 2026; doi:10.1038/d41586-026-02302-0Some researchers think the current eradication strategy is outdated. Plus, goats hurt their brains when they butt heads and what scientist will never hand over to AI.

Nature, Published online: 22 July 2026; doi:10.1038/d41586-026-02302-0

Some researchers think the current eradication strategy is outdated. Plus, goats hurt their brains when they butt heads and what scientist will never hand over to AI.

Here’s what’s next for the Artemis II astronauts

Nature, Published online: 22 July 2026; doi:10.1038/d41586-026-02020-7Newfound fame has proved to be stellar for some astronauts but harder for others. Will NASA’s popular crew need some space?

Nature, Published online: 22 July 2026; doi:10.1038/d41586-026-02020-7

Newfound fame has proved to be stellar for some astronauts but harder for others. Will NASA’s popular crew need some space?

Polio should have been eradicated by now. What’s plan B?

Nature, Published online: 22 July 2026; doi:10.1038/d41586-026-02229-6Amid funding cuts and political barriers, researchers are asking whether the campaign can ever succeed, and what to do next.

Nature, Published online: 22 July 2026; doi:10.1038/d41586-026-02229-6

Amid funding cuts and political barriers, researchers are asking whether the campaign can ever succeed, and what to do next.