Reference genomes and fossils revise bat family phylogeny and biogeography

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11007-3An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all known bat families.

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11007-3

An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all known bat families.

MMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11048-8Stability of extrachromosomal DNA (ecDNA) relies on microhomology-mediated end joining at fragile TA-rich sites, with FANCM suppressing break formation, suggest…

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11048-8

Stability of extrachromosomal DNA (ecDNA) relies on microhomology-mediated end joining at fragile TA-rich sites, with FANCM suppressing break formation, suggesting that Polθ disruption may destabilize ecDNA and sensitize ecDNA-driven tumours to therapeutic intervention.

A methanogen hydrolase reveals the structure of archaeal peptidoglycan

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11028-yArmA from Methanobrevibacter smithii, a dominant member of the human gut microbiome, is identified and characterized as a glycosyl hydrolase specific for cleavi…

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11028-y

ArmA from Methanobrevibacter smithii, a dominant member of the human gut microbiome, is identified and characterized as a glycosyl hydrolase specific for cleaving the cell wall of methanogens, revealing an unsuspected chemical structure of archaeal peptidoglycan that includes a previously unidentified sugar.

A design approach for bitopic kinase inhibitors

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11056-8Detailed analyses of ligand choice, linkage vector and linker length enabled the development of bitopic inhibitors of ABL1 and EGFR kinases, including an ABL1 i…

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11056-8

Detailed analyses of ligand choice, linkage vector and linker length enabled the development of bitopic inhibitors of ABL1 and EGFR kinases, including an ABL1 inhibitor with enhanced activity against resistance mutations and reduced off-target toxicity.

Hepatocytes promote liver metastasis of pancreatic cancer by providing serine

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11051-zMetastatic pancreatic ductal adenocarcinoma (PDAC) in the liver that lack the enzyme necessary to synthesize serine can reprogram hepatocytes to produce this am…

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11051-z

Metastatic pancreatic ductal adenocarcinoma (PDAC) in the liver that lack the enzyme necessary to synthesize serine can reprogram hepatocytes to produce this amino acid, thus promoting tumour growth and survival.

The human skeleton’s unique adaptations relied on gene regulatory changes

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02775-zVariants in genes involved in the production of extracellular matrix molecules could have enabled the skeletal adaptations that distinguish humans from other gr…

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02775-z

Variants in genes involved in the production of extracellular matrix molecules could have enabled the skeletal adaptations that distinguish humans from other great apes.

Banking records reveal characteristics of financial abuse

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11049-7An analysis of UK banking data reveals that people who reported being victim-survivors of financial abuse experience worse financial outcomes compared with a co…

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11049-7

An analysis of UK banking data reveals that people who reported being victim-survivors of financial abuse experience worse financial outcomes compared with a control group.

A plant that reproduces sexually but has clone-like offspring

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02789-7The plant Rhynchospora tenuis has no exchange of DNA between parental chromosomes during the production of male and female sex cells. Even so, it still transmit…

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02789-7

The plant Rhynchospora tenuis has no exchange of DNA between parental chromosomes during the production of male and female sex cells. Even so, it still transmits chromosomes and retains sexual reproduction. This unusual system restores parental genetic variants, leading to clonal-like inheritance across generations despite sex-cell production and fertilization.

Sequence-encoded hexagonal lattices in multichannel peptide nanofibrils

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11016-2Nine-residue peptides can encode discrete interaction motifs that direct the formation of hexagonal pores, which hierarchically tile into laterally expandable m…

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11016-2

Nine-residue peptides can encode discrete interaction motifs that direct the formation of hexagonal pores, which hierarchically tile into laterally expandable multichannel nanofibrils with defined topology.