Month: September 2026

Topographic structure and function of locus coeruleus noradrenaline neurons

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11026-0Dorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, …

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11026-0

Dorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, reward-prediction errors and disregard of reward-predictive cues, supporting flexible learning behaviour.

AI tool turns any paper into an ‘agent’ that can collaborate and answer complex queries

Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02899-2The Paper2Agent system makes it easier for researchers to reproduce papers and understand work in unfamiliar fields, authors say.

Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02899-2

The Paper2Agent system makes it easier for researchers to reproduce papers and understand work in unfamiliar fields, authors say.

Evolution and heterogeneity of lethal metastatic bladder cancer subtypes

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11035-zA rapid autopsy programme provides valuable resources to enable detailed molecular and genetic analyses of the temporal evolution of aggressive histological sub…

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11035-z

A rapid autopsy programme provides valuable resources to enable detailed molecular and genetic analyses of the temporal evolution of aggressive histological subtypes and therapy resistance in metastatic bladder cancer.

Mutational constraints on RSV F and its neutralization by antibodies

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11030-4How respiratory syncytial virus mutations affect antibody neutralization is defined, and a biophysical model of the mechanism is provided, to show how Fab poten…

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11030-4

How respiratory syncytial virus mutations affect antibody neutralization is defined, and a biophysical model of the mechanism is provided, to show how Fab potency and epitope specificity combine to determine the effects of viral mutations on antibody neutralization.

Continuous-wave laser absorption spectroscopy of the thorium-229 nucleus

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11011-7Absorption spectroscopy of thorium-229 nuclear excited states in a thorium-doped calcium fluoride crystal demonstrates a path towards a much more efficient way …

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11011-7

Absorption spectroscopy of thorium-229 nuclear excited states in a thorium-doped calcium fluoride crystal demonstrates a path towards a much more efficient way to build a highly stable and robust solid-state optical nuclear clock.

Molecular computation that rolls energetically downhill

Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02878-7A DNA-based computer that operates by relaxing to thermodynamic equilibrium has been demonstrated on ten molecular programs, which completed computations in as …

Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02878-7

A DNA-based computer that operates by relaxing to thermodynamic equilibrium has been demonstrated on ten molecular programs, which completed computations in as little as one minute. Some programs were rerun using distinct inputs up to 25 times and others were scaled up to 100-bit computations — although this slowed them down substantially.

Transplanted human brain-tissue takes root in mice without a cortex

Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02927-1Extensive cellular integration might provide platform for in vivo testing of new therapies — plus, the AI tool that turns papers into ‘virtual corresponding aut…

Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02927-1

Extensive cellular integration might provide platform for in vivo testing of new therapies — plus, the AI tool that turns papers into ‘virtual corresponding authors’.

Development of a random background to understand ligand optimization

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11013-5An approach to improve efficiency and establish a background expectation for ligand potency optimization is described.

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11013-5

An approach to improve efficiency and establish a background expectation for ligand potency optimization is described.

Developmental xenocortication using human-derived organoids in mice

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11032-2Xenocortication with human neurons enables circuit- and behaviour-level analysis of neurodevelopment in mice.

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11032-2

Xenocortication with human neurons enables circuit- and behaviour-level analysis of neurodevelopment in mice.