Biomarkers of nivolumab benefit in resectable non-small cell lung cancer

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10925-6Potential predictive biomarkers of perioperative nivolumab therapy benefit in non-small cell lung cancer are identified from evaluable participants in the CheckMat…

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10925-6

Potential predictive biomarkers of perioperative nivolumab therapy benefit in non-small cell lung cancer are identified from evaluable participants in the CheckMate 77T trial.

Superconducting 2D cuprate with a single CuO<sub>2</sub> plane

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10857-1A high-quality, pristine monolayer cuprate superconductor with a single CuO2 plane is fabricated and used to identify two quantum critical phenomena emerging betwe…

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10857-1

A high-quality, pristine monolayer cuprate superconductor with a single CuO2 plane is fabricated and used to identify two quantum critical phenomena emerging between the Mott insulating phase and the superconducting phase.

Procognitive restoration of PV neuron plasticity in neurodevelopmental disorders

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10907-8Expression of Meis2 in hippocampal parvalbumin-expressing interneurons in an adult mouse model of neurodevelopmental disorders rescues experience-dependent plastic…

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10907-8

Expression of Meis2 in hippocampal parvalbumin-expressing interneurons in an adult mouse model of neurodevelopmental disorders rescues experience-dependent plasticity, improves memory and network function and suppresses seizures.

Evidence for the first globular cluster stellar stream beyond the Milky Way

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10878-wDeep Hubble Space Telescope imaging of the ultra-diffuse galaxy UGC 9050-Dw1 reveals an extragalactic globular cluster stream, with analysis and modelling probing …

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10878-w

Deep Hubble Space Telescope imaging of the ultra-diffuse galaxy UGC 9050-Dw1 reveals an extragalactic globular cluster stream, with analysis and modelling probing the rich dark matter content of the host galaxy.

Rb-driven transcription limits its tumour-suppressive effects in breast cancer

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10886-wCDK4/6 inhibition redirects Rb chromatin occupancy to activate oestrogen-responsive genes, counteracting its own ability to maintain therapeutic cell-cycle arrest.

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10886-w

CDK4/6 inhibition redirects Rb chromatin occupancy to activate oestrogen-responsive genes, counteracting its own ability to maintain therapeutic cell-cycle arrest.

Numerous bow shocks in the outer Helix Nebula

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10724-zShocks in the eastern outskirts of the Helix Nebula, detected in Hα emission with the MOTHRA telescope, provide evidence for the recycling of fragmented stellar ej…

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10724-z

Shocks in the eastern outskirts of the Helix Nebula, detected in Hα emission with the MOTHRA telescope, provide evidence for the recycling of fragmented stellar ejecta into the surrounding gas.

Cascading continental-scale floods across Europe in 1342–1343

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10888-8Tracing cascading continental-scale medieval megafloods across Europe indicates that current flood management is unprepared for such sequences, highlighting the ur…

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10888-8

Tracing cascading continental-scale medieval megafloods across Europe indicates that current flood management is unprepared for such sequences, highlighting the urgent need for proactive flood risk management strategies that account for unusual series of extreme flood events.

Structural mechanism governing the directionality of bridge recombination

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10903-yCryo-electron microscopy structures show how IS621 bridge recombinase mediates DNA excision, explaining its natural preference for insertion and informing the desi…

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10903-y

Cryo-electron microscopy structures show how IS621 bridge recombinase mediates DNA excision, explaining its natural preference for insertion and informing the design of programmable bridge-editing technologies.

Shared principles of human and bacterial antiviral immunity

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10756-5The Review describes shared ancient, conserved mechanisms between human antiviral immunity and bacterial anti-phage systems, outlining universal principles of path…

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10756-5

The Review describes shared ancient, conserved mechanisms between human antiviral immunity and bacterial anti-phage systems, outlining universal principles of pathogen sensing, signalling and effector function that reveal common rules governing host–virus interactions across life.