Alternate RNA decoding results in stable and abundant proteins in mammals

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10678-2Alternate RNA decoding, an understudied process, leads to peptide sequence modifications that can have substantial functional effects on protein stability, tissue-sp…

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10678-2

Alternate RNA decoding, an understudied process, leads to peptide sequence modifications that can have substantial functional effects on protein stability, tissue-specific proteomes and disease.

Zero-shot design of drug-binding proteins via neural iterative selection−expansion

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10670-wBy pairing two neural networks in an iterative optimization algorithm, small-molecule binding proteins can be designed from scratch with high accuracy, affinity and …

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10670-w

By pairing two neural networks in an iterative optimization algorithm, small-molecule binding proteins can be designed from scratch with high accuracy, affinity and success rates, showing promise for applications in drug delivery and sequestration.

GW250114 reveals signatures of post-merger black-hole horizon

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10696-0The observation of a direct wave after the merger of two black holes reveals signatures associated with the remnant black-hole horizon, establishing an observational…

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10696-0

The observation of a direct wave after the merger of two black holes reveals signatures associated with the remnant black-hole horizon, establishing an observational channel to directly measure frame-dragging effects in black-hole ergospheres and probe the horizon surface gravity.

Genetic diversity of late Neanderthals in northwestern Europe

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10625-1Genetic sequencing of multiple late Neanderthals living less than 52,500 years ago provides an overview of genetic diversity and demonstrates that even low-coverage …

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10625-1

Genetic sequencing of multiple late Neanderthals living less than 52,500 years ago provides an overview of genetic diversity and demonstrates that even low-coverage nuclear genome data can increase resolution of within-Neanderthal diversity.

Crude oil fractionation by means of mesoporous polyacrylonitrile membranes

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10677-3Porous polyacrylonitrile membranes—typically used as non-selective support layers—can be used to achieve effective molecular refining of crude oil at steady state, e…

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10677-3

Porous polyacrylonitrile membranes—typically used as non-selective support layers—can be used to achieve effective molecular refining of crude oil at steady state, enabling substantial reductions in energy consumption, cooling water, and CO2 emissions compared with distillation processes.