Epiblast diversification and blood formation in a human pregastrula

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10698-yHigh-resolution spatial transcriptome analysis of a human embryo at Carnegie stage 6 reveals three distinct developmental trajectories from the epiblast towards amni…

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10698-y

High-resolution spatial transcriptome analysis of a human embryo at Carnegie stage 6 reveals three distinct developmental trajectories from the epiblast towards amnion, primitive streak and axial mesoderm, and detects the initiation of haematopoiesis before gastrulation, originating from hypoblast rather than epiblast.

A global map of seagrass ecosystems

Nature, Published online: 24 June 2026; doi:10.1038/d41586-026-01805-0Combining satellite imagery and machine learning has created the first comprehensive map of seagrass meadows, in a boost for the conservation of these crucial ecosys…

Nature, Published online: 24 June 2026; doi:10.1038/d41586-026-01805-0

Combining satellite imagery and machine learning has created the first comprehensive map of seagrass meadows, in a boost for the conservation of these crucial ecosystems.

Detection of anisotropic cosmic structures on a gigaparsec scale

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10702-5Using the parameter-free Angular Distribution of Pairwise Distances for measuring directional correlations, evidence is found for coherent anisotropic structures ext…

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10702-5

Using the parameter-free Angular Distribution of Pairwise Distances for measuring directional correlations, evidence is found for coherent anisotropic structures extending over gigaparsec scales, challenging the assumption that the Universe becomes statistically isotropic on sufficiently large scales.

Long-sought chemical inhibitors of β-arrestin proteins

Nature, Published online: 24 June 2026; doi:10.1038/d41586-026-01894-xProteins called β-arrestins regulate signalling through members of the G protein-coupled receptor (GPCR) superfamily. Small molecules that bind directly to the β-arr…

Nature, Published online: 24 June 2026; doi:10.1038/d41586-026-01894-x

Proteins called β-arrestins regulate signalling through members of the G protein-coupled receptor (GPCR) superfamily. Small molecules that bind directly to the β-arrestins and inhibit their activities are the first chemical tools to probe their biology, opening avenues for transducer-targeted, pathway-specific GPCR therapeutics.

Optical cooling by interfacial charge transfer in 2D heterostructures

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10662-wOptical cooling in two-dimensional semiconductor heterostructures is demonstrated through phonon-assisted interfacial charge transfer, enabling cryogen-free thermal …

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10662-w

Optical cooling in two-dimensional semiconductor heterostructures is demonstrated through phonon-assisted interfacial charge transfer, enabling cryogen-free thermal management without stringent quantum-efficiency requirements.

Ductile alloys offering 100 MPa tensile strength at 2,400 °C

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10708-zA boron-stabilized oxide-strengthened tantalum alloy combines exceptional room-temperature ductility with record ultrahigh-temperature strength, enabling load-bearin…

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10708-z

A boron-stabilized oxide-strengthened tantalum alloy combines exceptional room-temperature ductility with record ultrahigh-temperature strength, enabling load-bearing applications above 2,000 °C.

A <i>Streptomyces</i> megacluster encodes synergistic biotin-targeting antibiotics

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10647-9In Streptomyces spp., a conserved biosynthetic gene megacluster produces an arsenal of distinct antimicrobials that converge on bacterial biotin biosynthesis as a na…

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10647-9

In Streptomyces spp., a conserved biosynthetic gene megacluster produces an arsenal of distinct antimicrobials that converge on bacterial biotin biosynthesis as a naturally evolved combination therapy.

Laser light switches on heat flow in ultra-thin structures

Nature, Published online: 24 June 2026; doi:10.1038/d41586-026-01803-2A temperature difference of more than 100 kelvin can be created between stacked layers of 2D material by irradiating them with laser light.

Nature, Published online: 24 June 2026; doi:10.1038/d41586-026-01803-2

A temperature difference of more than 100 kelvin can be created between stacked layers of 2D material by irradiating them with laser light.

A hidden predictor of sudden cardiac death uncovered by deep learning

Nature, Published online: 24 June 2026; doi:10.1038/d41586-026-01806-zA machine-learning model trained on thousands of electrocardiogram recordings identifies a previously unrecognized group of at-risk people.

Nature, Published online: 24 June 2026; doi:10.1038/d41586-026-01806-z

A machine-learning model trained on thousands of electrocardiogram recordings identifies a previously unrecognized group of at-risk people.

Daily briefing: Sperm whales have different dialects

Nature, Published online: 24 June 2026; doi:10.1038/d41586-026-02054-xWhales in different areas of the Mediterranean use varying patterns of clicks and pauses. Plus, a technique to make protein samples one billion times bigger and the …

Nature, Published online: 24 June 2026; doi:10.1038/d41586-026-02054-x

Whales in different areas of the Mediterranean use varying patterns of clicks and pauses. Plus, a technique to make protein samples one billion times bigger and the science of grief.