Fourier pixels for bidirectional light control

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10681-7A versatile platform of miniaturized Fourier-optics-based diffractive elements enables multifunctional pixels that fully control and sense the amplitude, phase and p…

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10681-7

A versatile platform of miniaturized Fourier-optics-based diffractive elements enables multifunctional pixels that fully control and sense the amplitude, phase and polarization of optical wavefronts for advanced photonic applications.

Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10697-zChronic dietary cholesterol activates Ral GTPases, which promote LDLR internalization and lysosomal degradation through RalBP1–REPS1 and CTSA, thereby reducing chole…

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10697-z

Chronic dietary cholesterol activates Ral GTPases, which promote LDLR internalization and lysosomal degradation through RalBP1–REPS1 and CTSA, thereby reducing cholesterol clearance, whereas CTSA inhibition restores LDLR function and may offer a therapeutic strategy for cardiovascular disease.

Chiral laser gyroscopes breaking the lock-in limit

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10684-4Ring laser gyroscope lock-in has been eliminated using spontaneous symmetry breaking in a He–Ne laser, enabling accurate near-zero rotation sensing without external …

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10684-4

Ring laser gyroscope lock-in has been eliminated using spontaneous symmetry breaking in a He–Ne laser, enabling accurate near-zero rotation sensing without external components, improving miniaturization and precision.

Global high-resolution mapping of seagrass to support conservation

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10704-3Global high-resolution mapping shows widespread seagrass loss and degradation since 2019, with most meadows outside protected areas, highlighting urgent conservation…

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10704-3

Global high-resolution mapping shows widespread seagrass loss and degradation since 2019, with most meadows outside protected areas, highlighting urgent conservation and climate-policy needs.

Immunological mechanisms of mRNA vaccines for infectious diseases

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10599-0A Review of the immunological mechanisms of mRNA–lipid-nanoparticle vaccines for infectious diseases discusses how the components of this vaccine platform can be mod…

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10599-0

A Review of the immunological mechanisms of mRNA–lipid-nanoparticle vaccines for infectious diseases discusses how the components of this vaccine platform can be modified to fine-tune immune responses against challenging pathogens.

Small-molecule modulation of β-arrestins

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10683-5Integrated pharmacological, biochemical, biophysical and structural analyses of small-molecule β-arrestin inhibitors show how they block β-arrestin engagement with a…

Nature, Published online: 24 June 2026; doi:10.1038/s41586-026-10683-5

Integrated pharmacological, biochemical, biophysical and structural analyses of small-molecule β-arrestin inhibitors show how they block β-arrestin engagement with activated GPCRs, revealing their mechanism of action and uncovering a previously unrecognized allosteric regulatory site.