Sugar amplifies antibiotic disruption of gut microbes

Nature, Published online: 30 September 2026; doi:10.1038/d41586-026-02782-0People who underwent stem-cell transplantation and ate sugar-rich food had disrupted communities of gut microorganisms during antibiotic treatment.

Nature, Published online: 30 September 2026; doi:10.1038/d41586-026-02782-0

People who underwent stem-cell transplantation and ate sugar-rich food had disrupted communities of gut microorganisms during antibiotic treatment.

Function-preserving watermarking of AI-generated proteins

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-10965-ySynthIDBio watermarks AI-generated protein sequences and structures while preserving function, enabling provenance detection and offering a proof-of-concept too…

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-10965-y

SynthIDBio watermarks AI-generated protein sequences and structures while preserving function, enabling provenance detection and offering a proof-of-concept tool for biosecurity and information integrity.

Harmful tau spreads like self-propagating prion proteins

Nature, Published online: 30 September 2026; doi:10.1038/d41586-026-02778-wStructural studies support the idea that fibrillized tau protein, a feature of neurodegenerative disorders, acts as a prion-like template to induce misfolding i…

Nature, Published online: 30 September 2026; doi:10.1038/d41586-026-02778-w

Structural studies support the idea that fibrillized tau protein, a feature of neurodegenerative disorders, acts as a prion-like template to induce misfolding in healthy tau.

Dynamic protrusions mediate crawling motility in Asgard archaea

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11063-9Anoxic live-cell imaging shows actin-dependent crawling motility and dynamic protrusions in Asgard archaea, providing insights into cellular innovations that ma…

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11063-9

Anoxic live-cell imaging shows actin-dependent crawling motility and dynamic protrusions in Asgard archaea, providing insights into cellular innovations that may have contributed to eukaryotic evolution.

Carbene transfer from thianthrenium ylides for cyclopropanation

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11108-zThianthrenium ylides can be used as a general platform for metal–carbene generation and transfer, including cyclopropanation, σ-bond insertion and sigmatropic r…

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11108-z

Thianthrenium ylides can be used as a general platform for metal–carbene generation and transfer, including cyclopropanation, σ-bond insertion and sigmatropic rearrangements.

Wafer-scale epitaxy growth of high-mobility p-type boron carbon nitride

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11047-9A dual-precursor chemical system is used to achieve wafer-scale epitaxy growth of boron carbon nitride, a high-performance p-type semiconductor, for potential i…

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11047-9

A dual-precursor chemical system is used to achieve wafer-scale epitaxy growth of boron carbon nitride, a high-performance p-type semiconductor, for potential integration in efficient 2D materials for electronics.

Human genetics implicates a BACH2–NRF2 axis in fetal haemoglobin activation

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11113-2BACH2 restrains activation of the fetal-haemoglobin-encoding γ-globin genes, while loss of BACH2 enhances NRF2 chromatin occupancy and promotes the formation of…

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11113-2

BACH2 restrains activation of the fetal-haemoglobin-encoding γ-globin genes, while loss of BACH2 enhances NRF2 chromatin occupancy and promotes the formation of activation foci at the γ-globin genes.

γδ T cell receptor dependencies define a unique immunosurveillance modality

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11076-4Tissue-resident γδ T cells mount rapid, innate-like stress responses that require γδ T cell receptor signalling, revealing lineage-specific receptor dependence …

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11076-4

Tissue-resident γδ T cells mount rapid, innate-like stress responses that require γδ T cell receptor signalling, revealing lineage-specific receptor dependence that underpins their conserved roles in immunosurveillance and informs therapeutic deployment.

Transcription pause and elongation regulators mediate somatic hypermutation

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11092-4The molecular factors and mechanisms that mediate the chromatin recruitment of activation-induced deaminase and the generation of its stalled polymerase II subs…

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11092-4

The molecular factors and mechanisms that mediate the chromatin recruitment of activation-induced deaminase and the generation of its stalled polymerase II substrate during somatic hypermutation are identified.

Is exposomics the key to making personalized medicine a reality?

Nature, Published online: 30 September 2026; doi:10.1038/d41586-026-02958-8Scientists say tailored disease treatments require a comprehensive assessment of a person’s lifelong environmental exposures.

Nature, Published online: 30 September 2026; doi:10.1038/d41586-026-02958-8

Scientists say tailored disease treatments require a comprehensive assessment of a person’s lifelong environmental exposures.