Transplanted human brain-tissue takes root in mice without a cortex

Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02927-1Extensive cellular integration might provide platform for in vivo testing of new therapies — plus, the AI tool that turns papers into ‘virtual corresponding aut…

Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02927-1

Extensive cellular integration might provide platform for in vivo testing of new therapies — plus, the AI tool that turns papers into ‘virtual corresponding authors’.

Development of a random background to understand ligand optimization

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11013-5An approach to improve efficiency and establish a background expectation for ligand potency optimization is described.

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11013-5

An approach to improve efficiency and establish a background expectation for ligand potency optimization is described.

Developmental xenocortication using human-derived organoids in mice

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11032-2Xenocortication with human neurons enables circuit- and behaviour-level analysis of neurodevelopment in mice.

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11032-2

Xenocortication with human neurons enables circuit- and behaviour-level analysis of neurodevelopment in mice.

Reimagining research papers as interactive and reliable AI agents

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11044-yPaper2Agent converts research papers into interactive artificial intelligence agents by turning manuscripts, code and data into model context protocol-based too…

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11044-y

Paper2Agent converts research papers into interactive artificial intelligence agents by turning manuscripts, code and data into model context protocol-based tool-invoking systems that reproduce original results, answer new scientific queries and collaborate to generate novel insights.

Mitochondrial fission factor senses and governs ferroptosis

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11020-6The mitochondrial–peroxisomal fission adaptor MFF is identified as a selective pro-ferroptotic mediator, and the newly developed MFF–SPARK sensor enables high-c…

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11020-6

The mitochondrial–peroxisomal fission adaptor MFF is identified as a selective pro-ferroptotic mediator, and the newly developed MFF–SPARK sensor enables high-content screening of ferroptosis-sensitizing compounds and the discovery of upstream regulators of MFF.

Electroluminescent photoresists extending lithographic scaling to OLEDs

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11042-0Electroluminescent photoresists synthesized via atom transfer radical polymerization can be directly patterned by ultraviolet and electron-beam lithography, and…

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11042-0

Electroluminescent photoresists synthesized via atom transfer radical polymerization can be directly patterned by ultraviolet and electron-beam lithography, and used to fabricate monolithic, multicolour organic-light-emitting-diode micro-pixel arrays.

Virus-like particles observed assembling in real time

Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02644-9Scientists have long dreamt of being able to track and analyse each step in the assembly of a virus’s protein shell. An ingenious experiment shows how this can …

Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02644-9

Scientists have long dreamt of being able to track and analyse each step in the assembly of a virus’s protein shell. An ingenious experiment shows how this can be done.

Assessing biological degradation of non-hydrolysable synthetic polymers

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-10918-5The evidence for biological degradation of non-hydrolysable synthetic polymers is critically evaluated to propose best-practice principles for experimental desi…

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-10918-5

The evidence for biological degradation of non-hydrolysable synthetic polymers is critically evaluated to propose best-practice principles for experimental design that should promote reproducibility and impact across this field.

Electrically controllable superconducting memory effect in UTe<sub>2</sub>

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11015-3Observations of a memory effect in the p-wave superconductor candidate UTe2, which can be controlled by varying the strength and duration of the electrically ap…

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11015-3

Observations of a memory effect in the p-wave superconductor candidate UTe2, which can be controlled by varying the strength and duration of the electrically applied stimuli, are described.

Marine bacteria cooperate to break down complex algal carbohydrates

Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02873-yMarine algae produce sulfated carbohydrates called fucoidans that are chemically too complex for any bacteria to digest alone. Instead, marine bacteria split th…

Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02873-y

Marine algae produce sulfated carbohydrates called fucoidans that are chemically too complex for any bacteria to digest alone. Instead, marine bacteria split the task between them in a modular fashion: some strains degrade the molecular backbone, whereas others remove the side branches.