Cohesin reshapes replication fork contacts to aid fork slowing and reversal

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11034-0Cohesin-mediated loop extrusion limits sister-fork coupling and tethers nearby replication forks under replication stress, promoting fork reversal and slowing f…

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11034-0

Cohesin-mediated loop extrusion limits sister-fork coupling and tethers nearby replication forks under replication stress, promoting fork reversal and slowing fork progression to safeguard genome stability.

Overmassive black holes and little red dots naturally form in simulations

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-10985-8Observations from the JWST reveal an unexpectedly abundant population of little red dots and overmassive black holes in the early Universe, which are confirmed …

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-10985-8

Observations from the JWST reveal an unexpectedly abundant population of little red dots and overmassive black holes in the early Universe, which are confirmed by their formation in fully cosmological radiation-hydrodynamic simulations.

Author Correction: Obesity rise plateaus in developed nations and accelerates in developing nations

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11135-wAuthor Correction: Obesity rise plateaus in developed nations and accelerates in developing nations

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11135-w

Author Correction: Obesity rise plateaus in developed nations and accelerates in developing nations

Topographic structure and function of locus coeruleus noradrenaline neurons

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11026-0Dorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, …

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11026-0

Dorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, reward-prediction errors and disregard of reward-predictive cues, supporting flexible learning behaviour.

AI tool turns any paper into an ‘agent’ that can collaborate and answer complex queries

Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02899-2The Paper2Agent system makes it easier for researchers to reproduce papers and understand work in unfamiliar fields, authors say.

Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02899-2

The Paper2Agent system makes it easier for researchers to reproduce papers and understand work in unfamiliar fields, authors say.

Evolution and heterogeneity of lethal metastatic bladder cancer subtypes

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11035-zA rapid autopsy programme provides valuable resources to enable detailed molecular and genetic analyses of the temporal evolution of aggressive histological sub…

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11035-z

A rapid autopsy programme provides valuable resources to enable detailed molecular and genetic analyses of the temporal evolution of aggressive histological subtypes and therapy resistance in metastatic bladder cancer.

Mutational constraints on RSV F and its neutralization by antibodies

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11030-4How respiratory syncytial virus mutations affect antibody neutralization is defined, and a biophysical model of the mechanism is provided, to show how Fab poten…

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11030-4

How respiratory syncytial virus mutations affect antibody neutralization is defined, and a biophysical model of the mechanism is provided, to show how Fab potency and epitope specificity combine to determine the effects of viral mutations on antibody neutralization.

Continuous-wave laser absorption spectroscopy of the thorium-229 nucleus

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11011-7Absorption spectroscopy of thorium-229 nuclear excited states in a thorium-doped calcium fluoride crystal demonstrates a path towards a much more efficient way …

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11011-7

Absorption spectroscopy of thorium-229 nuclear excited states in a thorium-doped calcium fluoride crystal demonstrates a path towards a much more efficient way to build a highly stable and robust solid-state optical nuclear clock.

Molecular computation that rolls energetically downhill

Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02878-7A DNA-based computer that operates by relaxing to thermodynamic equilibrium has been demonstrated on ten molecular programs, which completed computations in as …

Nature, Published online: 16 September 2026; doi:10.1038/d41586-026-02878-7

A DNA-based computer that operates by relaxing to thermodynamic equilibrium has been demonstrated on ten molecular programs, which completed computations in as little as one minute. Some programs were rerun using distinct inputs up to 25 times and others were scaled up to 100-bit computations — although this slowed them down substantially.