Vast cellular gene-expression atlas could transform how scientists understand brain ageing and disease

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02770-4Single-nucleus RNA sequencing captures molecular changes in the prefrontal cortex across the lifespan and in health and disease.

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02770-4

Single-nucleus RNA sequencing captures molecular changes in the prefrontal cortex across the lifespan and in health and disease.

Stacking-induced direct band gap in CVD-grown 1H MoS<sub>2</sub> bilayers

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11069-3Atomically aligned 1H bilayer MoS2 exhibits a direct band gap, enhanced excitonic emission and stronger valley polarization, establishing its potential for adva…

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11069-3

Atomically aligned 1H bilayer MoS2 exhibits a direct band gap, enhanced excitonic emission and stronger valley polarization, establishing its potential for advanced optoelectronic and valleytronic applications.

Landmark map of human brain’s gene activity holds clues to Alzheimer’s disease and more

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02947-xThe atlas of gene expression in the prefrontal cortex was created using samples from almost 1,500 donors of all ages — from infants to centenarians.

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02947-x

The atlas of gene expression in the prefrontal cortex was created using samples from almost 1,500 donors of all ages — from infants to centenarians.

Agricultural liming is a carbon sink in the Mississippi River Basin

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11040-2Century-scale records of agricultural liming and anthropogenic acidity inputs for the Mississippi River Basin show that agricultural liming has acted as a net c…

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11040-2

Century-scale records of agricultural liming and anthropogenic acidity inputs for the Mississippi River Basin show that agricultural liming has acted as a net carbon sink over the past century.

Lifespan single-cell transcriptomic atlas of the human prefrontal cortex

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-10271-7The dorsolateral prefrontal cortex exhibits non-linear, cell-type-specific transcriptional trajectories characterized by dynamic remodelling during development,…

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-10271-7

The dorsolateral prefrontal cortex exhibits non-linear, cell-type-specific transcriptional trajectories characterized by dynamic remodelling during development, relative stability in midlife and selective molecular reactivation in late adulthood.

Gravitational tug-of-war inside Earth is changing the length of our days

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-03018-xA battle of forces, driven by the motion of Earth’s core, can explain small variations in the planet’s rotation, study finds.

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-03018-x

A battle of forces, driven by the motion of Earth’s core, can explain small variations in the planet’s rotation, study finds.

Anomalous metal and superconducting phases in rhombohedral graphene

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11033-1Observations of rhombohedral graphene on a WSe2 substrate at varying temperature, magnetic field and current indicate the presence of regions of gate space with…

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11033-1

Observations of rhombohedral graphene on a WSe2 substrate at varying temperature, magnetic field and current indicate the presence of regions of gate space with zero-resistance superconductivity alongside others with finite saturation resistance.

Efficient yet stable large perovskite solar modules made using surface treatment

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02937-zNon-uniformities in the layer of passivator molecules, which are used to fix defects and protect the surface of perovskite material in solar cells, can limit th…

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02937-z

Non-uniformities in the layer of passivator molecules, which are used to fix defects and protect the surface of perovskite material in solar cells, can limit the durability of the resulting modules. Large modules treated instead with chemically stable lead carboxylate passivators were efficient, reliable and had a higher yield than did commercial silicon modules.

Targeting ZMYND8 unleashes IL-2 signalling to override T cell exhaustion

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11059-5ZMYND8 suppresses IL-2R–STAT5 signalling by inhibiting p300-mediated transcriptional activation of Il2ra to enforce CD8+ T cell terminal exhaustion, and its del…

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11059-5

ZMYND8 suppresses IL-2R–STAT5 signalling by inhibiting p300-mediated transcriptional activation of Il2ra to enforce CD8+ T cell terminal exhaustion, and its deletion boosts effector-like states and markedly enhances antiviral and antitumour immunity.